Anti-macroH2A.2 histone antibodies are used for the immunodetection of the protein encoded by the MACROH2A2 gene. In humans, the canonical protein has a reported length of 372 amino acid residues and a mass of 40.1 kDa. Its subcellular localization is in the nucleus. It is noted to be involved in brain development and the regulation of transcription. Other names for this target antigen include H2A histone family member Y2, core histone macroH2A2.2, histone macroH2A2, mH2A2, and core histone macro-H2A.2. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.