Anti-H1.4 linker histone, cluster member antibodies are used for the immunodetection of the protein encoded by the H1-4 gene. In humans, the canonical protein has a reported length of 219 amino acid residues and a mass of 21.9 kDa. Its subcellular localization is in the nucleus and chromosomes. A member of the Histone H1/H5 protein family, it is known to be involved with the regulation of transcription. Post-translational modifications have been described, including acetylation and phosphorylation. The gene encoding this protein is implicated in Rahman syndrome. Other names for this target antigen include H1E, H1F4, H1s-4, HIST1H1E, RMNS, dJ221C16.5, histone H1.4, and H1.4. Gene orthologs have been identified in the mouse, rat, bovine and chimpanzee species.