Anti-COPI coat complex subunit beta 2 antibodies are used for the immunodetection of the protein encoded by the COPB2 gene. In humans, the canonical protein has a reported length of 906 amino acid residues and a mass of 102.5 kDa. Its subcellular localization is in the membrane, cytoplasmic vesicles, Golgi, and cytoplasm. Alternative splicing is reported to yield 2 different isoforms for this protein. A member of the WD repeat COPB2 protein family, it is known to be involved with Golgi transport and intracellular protein transport. The gene encoding this protein is implicated in Microcephaly. Other names for this target antigen include OPDD, beta'-COP, coatomer subunit beta', beta'-coat protein, betaprime-COP, and MCPH19. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.