Anti-nuclear VCP like antibodies are used for the immunodetection of the protein encoded by the NVL gene. In humans, the canonical protein has a reported length of 856 amino acid residues and a mass of 95.1 kDa. Its subcellular localization is in the nucleus. Alternative splicing is reported to yield 5 different isoforms for this protein. It is widely expressed across many tissue types. A member of the AAA ATPase protein family, it is known to participate in the assembly of the telomerase holoenzyme and effecting of telomerase activity via its interaction with TERT. Other names for this target antigen include nuclear valosin-containing protein-like, NVLp, and NVL2. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.