Anti-ADAMTS20 antibodies are used in the immunodetection of the protein ADAM metallopeptidase with thrombospondin type 1 motif 20. In humans, the canonical protein has a reported length of 1910 amino acid residues and a mass of 214.7 kDa. Its subcellular localization is in the extracellular matrix and is secreted. Up to 3 different isoforms have been reported for this protein. ADAMTS20 is believed to play a role in tissue-remodeling process occurring in both normal and pathological conditions. Post-translational modifications have been described, including N-glycosylation and protein cleavage.
The ADAMTS20 marker can be used to identify Cerebral Cortex MGE Interneurons, Brain Interneurons, and Lower Rhombic Lip Neurons.* Synonyms for this target antigen include a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 20, and A disintegrin and metalloproteinase with thrombospondin motifs 20. ADAMTS20 gene orthologs have been reported in the mouse, rat, bovine, frog, chimpanzee and chicken species. Western Blot is a widely used application for the ADAMTS20 antibodies listed below. In addition, ELISA is also a common application.
*HuBMAP Human Reference Atlas v1.4