Anti-H2BC5 antibodies are used in the immunodetection of the protein H2B clustered histone 5. In humans, the canonical protein has a reported length of 126 amino acid residues and a mass of 13.9 kDa. Its subcellular localization is in the nucleus and chromosomes. It is notably widely expressed in many tissue types. A member of the Histone H2B protein family, H2BC5 is an important component of nucleosome. Post-translational modifications have been described, including glycosylation, ubiquitination and phosphorylation. Synonyms for this target antigen include H2B/a, H2B/b, H2B/g, H2B/h, H2B/k, H2B/l, H2BFA, and H2B.1B.