Anti-SET antibodies are used in the immunodetection of the protein SET nuclear proto-oncogene. In humans, the canonical protein has a reported length of 290 amino acid residues and a mass of 33.5 kDa. Its subcellular localization is in the nucleus, ER, and cytoplasm. Up to 4 different isoforms have been reported for this protein. It is widely expressed across many tissue types. A member of the Nucleosome assembly protein (NAP) protein family, SET is known to be a multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning. Post-translational modifications have been described, including methylation, acetylation, protein cleavage and phosphorylation. The SET gene has been associated with the disease, Intellectual developmental disorder. Synonyms for this target antigen include I2PP2A, IGAAD, IPP2A2, MRD58, PHAPII, TAF-I, TAF-IBETA, and 2PP2A. SET gene orthologs have been reported in the mouse, rat, bovine, frog, chimpanzee and chicken species.