PhosphoPair PLK-1 (Thr210) Antibody Set 699956 from BioLegend

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Pharmaceuticals (Basel)
April 24 2022

Fig 1: PLK1 expression correlates with poor overall survival of NB patients. Kaplan–Meier analysis of PLK1 gene showing poor overall probability of NB patients’ survival. (A) Kocak dataset (N = 649 patients). (B) SEQC dataset (N = 498 patients). (C) Versteeg dataset (N = 88 patients). (D–F) Correlation of PLK1 expression with NB stage progression. (D) Kocak dataset (E) SEQC dataset (F) Versteeg dataset. N represents the number of patient samples.
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Pharmaceuticals (Basel)
April 24 2022

Fig 2: HMN-214 inhibits critical NB regulatory genes. Gene expression analysis of PLK1 pathway and cell cycle regulatory genes in response to HMN-214 in SH-SY5Y cells. (A) PLK1, (B) WEE1, (C) CDK1, (D) CDK2, (E) MYC, (F) CCNB1 (Cyclin-B1), (G) CHEK1 (CHK1), (H) CHEK2 (CHK2), and (I) MDM2. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001.
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Pharmaceuticals (Basel)
April 24 2022

Fig 3: HMN-214 inhibits PLK1 activation. (A) Western blot analysis of PLK1, pPLK1 (Thr210), and CDK1 in response to HMN-214 treatment in SH-SY5Y cells. CyPB is used as loading control. (B,C) Densiometric analysis of (B) pPLK1 and (C) CDK1. *** p < 0.001.

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PhosphoPair PLK-1 (Thr210) Antibody Set

BioLegend's PhosphoPair PLK-1 (Thr210) Antibody Set monoclonal antibody. The PhosphoPair PLK-1 (Thr210) Antibody Set was generated using PLK1 as the antigen. It reacts with Homo Sapiens, and Human. This antibody has been shown to work in applications such as: Western Blot.

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PhosphoPair PLK-1 (Thr210) Antibody Set [3F8; 2A3]

Pharmaceuticals (Basel)

Pharmaceuticals (Basel)

Pharmaceuticals (Basel)

PhosphoPair PLK-1 (Thr210) Antibody Set from BioLegend

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BioLegend

Citations (1)

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PhosphoPair PLK-1 (Thr210) Antibody Set from BioLegend

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