Anti-CD209 antibodies are used in the immunodetection of the protein CD209 molecule. In humans, the canonical protein has a reported length of 404 amino acid residues and a mass of 45.8 kDa. Up to 12 different isoforms have been reported for this protein. It is reported to be highly expressed in the dendritic cells and in DC-residing tissues. CD209 is known to be involved with adaptive immune responses and endocytosis. Post-translational modifications have been described, including glycosylation.
The CD209 marker can be used to identify Blood Vessel Endothelial Cells, Lymphatic Vessel Endothelial Cells, and Uterine Macrophages.* Synonyms for this target antigen include CLEC4L, DC-SIGN, DC-SIGN1, hDC-SIGN, CD209 antigen, and CDSIGN. CD209 gene orthologs have been reported in the rat and chimpanzee species. Over 340 citations in the literature describe the use of CD209 antibodies in research. Flow Cytometry is a widely used application for these antibodies. Western Blot and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4