What are SOX17 antibodies?
Anti-SOX17 antibodies are immunoglobulins that specifically recognize and bind SOX17, the gene encoding transcription factor SOX-17 in humans. In research applications, these antibodies are used to detect SOX17 in tissue samples, cell lysates, and cultured cells. SOX17 is a transcriptional regulator that binds target DNA sequences to modulate Wnt signaling and is required for normal definitive gut endoderm formation, embryonic heart tube looping, and postnatal vascular development. Because SOX17 governs endoderm and endothelial lineage specification, it is a widely used marker in developmental and stem cell research.
Catalog highlights and purchasing considerations
About the Biocompare SOX17 antibody catalog
The Biocompare antibody search tool lists SOX17 antibodies from a wide range of suppliers, with western blot, immunofluorescence, and immunocytochemistry among the most common validated applications. Listings may also appear under the gene symbol SOX17, the designation used across most product names in this catalog. Several SOX17 antibodies mentioned here have been cited across a range of developmental biology research, including studies on generating human primordial germ cell-like cells from pluripotent stem cells, PTEN-driven mesendoderm specification in human organoids through suppression of retinoic acid signaling, and induced pluripotent stem cell line generation from patients carrying disease-associated gene mutations.
Considerations when choosing a SOX17 antibody for research
Confirm that the antibody's intended target is accurate, as many genes carry synonym symbols that can create ambiguity across suppliers. Specificity should be verified against the immunogen sequence or region listed on the product datasheet, since antibodies raised against different epitopes of the same protein can behave differently across applications. Beyond specificity, several target-related attributes can affect antibody binding, including subcellular location, extracellular and cytoplasmic domain boundaries for membrane-associated targets, tissue specificity, post-translational modifications, and the presence of additional isoforms or disease-associated variants. In parallel, antibody-specific selection criteria warrant consideration, including clonality (monoclonal versus polyclonal), host species, species reactivity, and conjugate or label choice suited to the detection method. Supplier validation data, such as western blot bands at the expected molecular weight, immunohistochemistry staining patterns consistent with known tissue distribution, and knockout or knockdown controls, should also be carefully reviewed before purchase.