Anti-NMUR2 antibodies are used in the immunodetection of the protein neuromedin U receptor 2. In humans, the canonical protein has a reported length of 415 amino acid residues and a mass of 47.7 kDa. Its subcellular localization is in the cell membrane. It is reported to be highly expressed in the the CNS, particularly in the medulla oblongata, pontine reticular formation, spinal cord, and thalamus. A member of the G-protein coupled receptor 1 protein family, NMUR2 is a known receptor for the neuromedin-U and neuromedin-S neuropeptides. Post-translational modifications have been described, including glycosylation.
The NMUR2 marker can be used to identify Dorsal Excitatory Neurons.* Synonyms for this target antigen include G-protein coupled receptor TGR-1, growth hormone secretagogue receptor family, member 4, and G-protein coupled receptor FM-4. NMUR2 gene orthologs have been reported in the mouse, rat, bovine, frog, chimpanzee and chicken species. A number of NMUR2 antibodies have been mentioned in research publications and have associated citations. Immunohistochemistry is a widely used application for these antibodies. In addition, Western Blot is also a common application.
*HuBMAP Human Reference Atlas v1.4