Anti-PRPH antibodies are used in the immunodetection of the protein peripherin. In humans, the canonical protein has a reported length of 470 amino acid residues and a mass of 53.7 kDa. Its subcellular localization is in the cytoplasm. Up to 2 different isoforms have been reported for this protein. It is reported to be expressed in the neurons of the outer hair cells in the organ of Corti and to a lesser extent in type I spiral ganglion cells. It is a member of the Intermediate filament protein family.
The PRPH marker can be used to identify Large Intestine Ganglion Cells, Ganglion Cells, and Motor Neurons.* Synonyms for this target antigen include PRPH1, neurofilament 4 (57kD), and NEF4. PRPH gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. A number of PRPH antibodies have been mentioned in research publications and have associated citations. Western Blot is a widely used application for these antibodies. In addition, Immunohistochemistry is also a common application.
*HuBMAP Human Reference Atlas v1.4