Anti-CD79a molecule antibodies are used for the immunodetection of the protein encoded by the CD79A gene. In humans, the canonical protein has a reported length of 226 amino acid residues and a mass of 25 kDa. Its subcellular localization is in the cell membrane. Alternative splicing is reported to yield 2 different isoforms for this protein. It is known to be required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation.
The CD79a molecule marker can be used to characterize B Cells, Large Intestine Lamina Propria Lymphocytes, Regulatory T Cells, Plasma Cells, and Naive B Cells.* Other names for this target antigen include IGAlpha, MB-1, MB1, B-cell antigen receptor complex-associated protein alpha chain, CD79a antigen (immunoglobulin-associated alpha), and IGA. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish and chimpanzee species. Over 290 citations in the literature describe the use of CD79a molecule antibodies in research. Flow Cytometry, Western Blot, Immunofluorescence, and Immunohistochemistry are common applications for these antibodies.
*HuBMAP Human Reference Atlas v1.4