Anti-NECTIN2 antibodies are used in the immunodetection of the protein nectin cell adhesion molecule 2. In humans, the canonical protein has a reported length of 538 amino acid residues and a mass of 57.7 kDa. Its subcellular localization is in the cell membrane. Up to 2 different isoforms have been reported for this protein. It is ubiquitously expressed across many tissue types. A member of the Nectin protein family, NECTIN2 is known to be involved with cytoskeleton organization and cellular localization. Post-translational modifications have been described, including glycosylation.
The NECTIN2 marker can be used to identify Blood Vessel Endothelial Cells.* Synonyms for this target antigen include HVEB, PRR2, PVRL2, PVRR2, herpesvirus entry protein B, and CD112. NECTIN2 gene orthologs have been reported in the mouse, rat, bovine, frog and chimpanzee species. Over 170 citations in the literature describe the use of NECTIN2 antibodies in research. Flow Cytometry is a widely used application for these antibodies. Western Blot and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4