Nectin-2/CD112 Antibody AF2229 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemNectin-2/CD112 Antibody
CompanyR&D Systems, a Bio-Techne Brand
Price $499.00Supplier Page View Company Product Page
Catalog NumberAF2229
NCBI Gene AliasesPVRR2, PRR2, HVEB, PVRL2, CD112
ApplicationsImmunohistochemistry,Immunoprecipitation,Western Blot,Immunohistochemistry-Paraffin,Simple Western,Immunocytochemistry
Quantity100 ug (also 25 ug)
ReactivityHuman
HostGoat
Conjugate/TagUnconjugated
FormatLyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS
TargetNectin-2/CD112
IsotypeIgG
NCBI Full Gene Namenectin cell adhesion molecule 2
ClonalityPolyclonal
ImmunogenMouse myeloma cell line NS0-derived recombinant human Nectin-2/CD112 isoform a, Gln32-Leu360, Accession # NP_002847
ConcentrationLYOPH
PurityAntigen Affinity-purified
Antibody TypePrimary Antibodies
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution

Specifications/Features

Available conjugates: Available conjugates: Unconjugated

Specificity: Detects human Nectin-2/CD112 in direct ELISAs and Western blots. In direct ELISAs and Western blots, less than 2% cross-reactivity with recombinant human (rh) Nectin-1, rhNectin-3 and rhNectin-4 is observed.

Sizes Available: 100 ug (also 25 ug)

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) CRISPR activation screen identifies BCL-2 proteins and B3GNT2 as drivers of cancer resistance to T cell-mediated cytotoxicityNature communicationsMarch 25, 2022Joung J, Kirchgatterer PC, Singh A, Cho JH, Nety SP, Larson RC, Macrae RK, Deasy R, Tseng YY, Maus MV, et al.(Santa Cruz Biotechnology sc-365539, 1:200), CD58 (Thermo Fisher Scientific MA5800, 1:200), NECTIN2 (R&D Systems AF2229, 1:2000), HLA-A (Abcam ab52922, 1:5000), TNFRSF1A (Santa Cruz Biotechnology sc-8436, 1:200), IFNGR2

(2) Human allogenic γδ T cells kill patient-derived glioblastoma cells expressing high levels of DNAM-1 ligandsOncoimmunologyJanuary 1, 2022Choi H, Lee Y, Park SA, Lee JH, Park J, Park JH, Lee HK, Kim TG, Jeun SS, Ahn S.Thermo Fisher Scientific, MA), for PVR (clone D8A5G, Cell Signaling Technology, MA), Nectin-2 (clone AF2229, R&D Systems, MN), Alexa 488-conjugated goat anti-rat IgG (A-11006, I Thermo Fisher Scientific, MA),

(3) Blockade of checkpoint receptor PVRIG unleashes anti-tumor immunity of NK cells in murine and human solid tumorsJournal of hematology & oncologyJune 26, 2021Li Y, Zhang Y, Cao G, Zheng X, Sun C, Wei H, Tian Z, Xiao W, Sun R, Sun H.followed by incubation with primary antibodies to human PVRIG (Clone 2, generated in house) and PVRL2 (AF2229, R&D Systems, Minneapolis, USA) respectively. The signal was detected using the DAB Peroxidase Substrate

(4) Junctional Localization of Septin 2 Is Required for Organization of Junctional Proteins in Static Endothelial MonolayersArteriosclerosis, thrombosis, and vascular biologyJanuary 1, 2021Kim J, Cooper JA.antibody (9F9.F9) were obtained and used as described.20 Anti-human nectin-2 antibody (Catalog no. AF2229) and anti-human afadin antibody (clone 851204) were obtained from R&D Systems (Minneapolis, MN). Anti-human

(5) The Ubiquitin-proteasome pathway regulates Nectin2/CD112 expression and impairs NK cell recognition and killingEuropean journal of immunologyJune 1, 2019Molfetta R, Milito ND, Zitti B, Lecce M, Fionda C, Cippitelli M, Santoni A, Paolini R.

(6) Tpl2 is required for VEGF-A-stimulated signal transduction and endothelial cell functionBiology openMay 17, 2019Fearnley GW, Abdul-Zani I, Latham AM, Hollstein MC, Ladbury JE, Wheatcroft SB, Odell AF, Ponnambalam S.#AF357, mouse-anti-VCAM-1 cat. #BBA5 (R&D Systems, Minneapolis, MN, USA), goat-anti-nectin 2 cat. #AF2229 (R&D Systems), rabbit-anti-ATF-2 cat. #35031, rabbit-anti-phospho-ATF-2 cat. #9221 (pT71), rabbit-anti-phospho-VEGFR2-Y1175

(7) Blockade of the checkpoint receptor TIGIT prevents NK cell exhaustion and elicits potent anti-tumor immunityNature immunologyJuly 1, 2018Zhang Q, Bi J, Zheng X, Chen Y, Wang H, Wu W, Wang Z, Wu Q, Peng H, Wei H, et al.

(8) Low-dose bortezomib increases the expression of NKG2D and DNAM-1 ligands and enhances induced NK and γδ T cell-mediated lysis in multiple myelomaOncotargetJanuary 24, 2017Niu C, Jin H, Li M, Zhu S, Zhou L, Jin F, Zhou Y, Xu D, Xu J, Zhao L, et al.

(9) Host nectin-1 is required for efficient Chlamydia trachomatis serovar E developmentFrontiers in cellular and infection microbiologyJanuary 1, 2014Hall JV, Sun J, Slade J, Kintner J, Bambino M, Whittimore J, Schoborg RV.anti-nectin-1 CK6 (sc-21722, Santa Cruz Biotechnology), anti-β-actin (MAB1501, Chemicon), anti-nectin-2 (AF2229, R&D systems), anti-HVEM (N-19) (sc-7766, Santa Cruz Biotechnology), anti-phospho-Akt (9271, Cell Signaling),

(10) p120 regulates endothelial permeability independently of its NH2 terminus and Rho bindingAmerican journal of physiology. Heart and circulatory physiologyJanuary 1, 2011Herron CR, Lowery AM, Hollister PR, Reynolds AB, Vincent PA.

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Nectin-2/CD112 Antibody

Nectin-2/CD112 Antibody

Nectin-2/CD112 Antibody

Nectin-2/CD112 Antibody

Nectin-2/CD112 Antibody

Nectin-2/CD112 Antibody from R&D Systems, a Bio-Techne Brand

Specifications/Features

R&D Systems, a Bio-Techne Brand

Citations (10)

Reviews

Nectin-2/CD112 Antibody from R&D Systems, a Bio-Techne Brand

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