Anti-EYA4 antibodies are used in the immunodetection of the protein EYA transcriptional coactivator and phosphatase 4. In humans, the canonical protein has a reported length of 639 amino acid residues and a mass of 69.5 kDa. Its subcellular localization is in the nucleus and cytoplasm. Up to 5 different isoforms have been reported for this protein. It is reported to be highly expressed in the heart and skeletal muscle. A member of the EYA protein family, Eya4 is reported to be a tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph).
The EYA4 marker can be used to identify Cerebral Cortex MGE Interneurons, Hippocampal Gyrus Chandelier Neurons, and Brain Interneurons.* Synonyms for this target antigen include DFNA10, eyes absent homolog 4, dJ78N10.1 (eyes absent), eyes absent-like protein 4, and CMD1J. EYA4 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Some Eya4 antibodies may have been used in research and have associated citations. Immunohistochemistry is a widely used application for these antibodies. ELISA, Western Blot, and Immunofluorescence are also common applications.
*HuBMAP Human Reference Atlas v1.4