Anti-AIFM2 antibodies are used in the immunodetection of the protein apoptosis inducing factor mitochondria associated 2. In humans, the canonical protein has a reported length of 373 amino acid residues and a mass of 40.5 kDa. Its subcellular localization is in the cell membrane, nucleus, mitochondria, and cytoplasm. Up to 2 different isoforms have been reported for this protein. It is notably expressed in most normal tissues as two transcripts of 18 and 40 kb in length, respectively. A member of the FAD-dependent oxidoreductase protein family, AIFM2 is known to be involved with the apoptotic pathway.
The AIFM2 marker can be used to identify Fibroblasts.* Synonyms for this target antigen include apoptosis-inducing factor (AIF)-like mitochondrion-associated inducer of death, apoptosis-inducing factor 2, apoptosis-inducing factor, mitochondrion-associated, 2, and ferroptosis suppressor protein 1. A number of AIFM2 antibodies have been mentioned in research publications and have associated citations. Western Blot is a widely used application for these antibodies. ELISA, Immunofluorescence, and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4