Anti-C5 antibodies are used in the immunodetection of the protein complement C5. In humans, the canonical protein has a reported length of 1676 amino acid residues and a mass of 188.3 kDa. It has been described to be a secreted protein. C5 is known to be involved with receptor-mediated signaling pathways and chemotaxis. Post-translational modifications have been described, including glycosylation. The C5 gene has been associated with the disease, Complement component 5 deficiency. Synonyms for this target antigen include C5a, CPAMD4, ECLZB, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4, and C5D. C5 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Over 80 citations in the literature describe the use of C5 antibodies in research. ELISA is a widely used application for these antibodies. In addition, Western Blot is also a common application.