Anti-Huntingtin antibodies are used for the immunodetection of the protein encoded by the HTT gene. In humans, the canonical protein has a reported length of 3142 amino acid residues and a mass of 347.6 kDa. Its subcellular localization is in the nucleus, cytoplasmic vesicles, and cytoplasm. It is reported to be expressed in the brain cortex. A member of the Huntingtin protein family, it is known to be involved with the apoptotic pathway and Golgi organization. The gene encoding this protein is implicated in Huntington disease. Other names for this target antigen include IT15, LOMARS, huntington disease protein, and HD. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Over 180 citations in the literature describe the use of Huntingtin antibodies in research. Western Blot is a widely used application for these antibodies. ELISA, Immunofluorescence, and Immunohistochemistry are also common applications.