Anti-USP22 antibodies are used in the immunodetection of the protein ubiquitin specific peptidase 22. In humans, the canonical protein has a reported length of 525 amino acid residues and a mass of 60 kDa. Its subcellular localization is in the nucleus. Alternative splicing is reported to yield 2 different isoforms for this protein. It is notably expressed in various tissues including heart and skeletal muscle, and weakly expressed in lung and liver. A member of the Peptidase C19 protein family, it is known to be involved with the cell cycle and chromatin organization. Synonyms for this target antigen include ubiquitin carboxyl-terminal hydrolase 22, deubiquitinating enzyme 22, ubiquitin specific protease 22, ubiquitin thioesterase 22, ubiquitin thiolesterase 22, and USP3L.