Anti-Transgelin antibodies are used for the immunodetection of the protein encoded by the TAGLN gene. In humans, the canonical protein has a reported length of 201 amino acid residues and a mass of 22.6 kDa. Its subcellular localization is in the cytoplasm. A member of the Calponin protein family, it is known to be involved with epithelial cell differentiation and muscle organ development.
The transgelin marker can be used to characterize Brain Vascular Non-Neuronal Cells, Smooth Muscle Cells, Vascular Smooth Muscle Cells, Myofibroblasts, and Bronchiolar Smooth Muscle Cells.* Other names for this target antigen include SM22-alpha, SMCC, TAGLN1, WS3-10, 22 kDa actin-binding protein, and SM22. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Over 290 citations in the literature describe the use of Transgelin antibodies in research. Immunohistochemistry is a widely used application for these antibodies. Western Blot and Immunofluorescence are also common applications.
*HuBMAP Human Reference Atlas v1.4