Anti-Granzyme A antibodies are used for the immunodetection of the protein encoded by the GZMA gene. In humans, the canonical protein has a reported length of 262 amino acid residues and a mass of 29 kDa. Its subcellular localization is in the cytoplasm and is secreted. A member of the Peptidase S1 protein family, it is known to be involved with the apoptotic pathway and immune response pathways. Post-translational modifications have been described, including glycosylation.
The granzyme A marker can be used to characterize Mature Natural Killer Cells and CD4+ ?ß Cytotoxic T Cells.* Other names for this target antigen include HFSP, CTL tryptase, Cytotoxic T-lymphocyte-associated serine esterase-3, Granzyme A (Cytotoxic T-lymphocyte-associated serine esterase-3; Hanukah factor serine protease), and CTLA3. Gene orthologs have been identified in the mouse, rat, bovine and chimpanzee species. Over 160 citations in the literature describe the use of Granzyme A antibodies in research. Western Blot, Immunofluorescence, and Immunohistochemistry are common applications for these antibodies.
*HuBMAP Human Reference Atlas v1.4