Anti-SEC11C antibodies are used in the immunodetection of the protein SEC11 homolog C, signal peptidase complex subunit. In humans, the canonical protein has a reported length of 192 amino acid residues and a mass of 21.5 kDa. Its subcellular localization is in the ER. It is notably expressed in the tonsil, spleen, and lymph node. A member of the Peptidase S26B protein family, SEC11C is reported to be a catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.
The SEC11C marker can be used to identify Plasma Cells.* Synonyms for this target antigen include SEC11-like 3, SEC11-like protein 3, SPase 21 kDa subunit, microsomal signal peptidase 21 kDa subunit, signal peptidase complex 21, and signal peptidase complex catalytic subunit SEC11C. SEC11C gene orthologs have been reported in the mouse, rat, bovine, frog, chimpanzee and chicken species. Western Blot is a widely used application for the SEC11C antibodies listed below. In addition, ELISA is also a common application.
*HuBMAP Human Reference Atlas v1.4