Anti-MMP16 antibodies are used in the immunodetection of the protein matrix metallopeptidase 16. In humans, the canonical protein has a reported length of 607 amino acid residues and a mass of 69.5 kDa. Its subcellular localization is in the extracellular matrix and cell membrane. Up to 2 different isoforms have been reported for this protein. It is found to be expressed in the heart, brain, placenta, ovary and small intestine. A member of the Peptidase M10A protein family, MMP16 is a reported endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Post-translational modifications have been described, including protein cleavage and glycosylation. Synonyms for this target antigen include MMP-X2, MT-MMP2, MT-MMP3, MT3-MMP, matrix metalloproteinase-16, MT-MMP 3, MT3MMP, and C8orf57. MMP16 gene orthologs have been reported in the mouse, rat, bovine, frog, chimpanzee and chicken species.