Anti-sirtuin 5 antibodies are used for the immunodetection of the protein encoded by the SIRT5 gene. In humans, the canonical protein has a reported length of 310 amino acid residues and a mass of 33.9 kDa. Its subcellular localization is in the nucleus, mitochondria, and cytoplasm. Alternative splicing is reported to yield 4 different isoforms for this protein. It is widely expressed across many tissue types. A member of the Sirtuin protein family, it is known to be involved with the regulation of apoptosis. Other names for this target antigen include NAD-dependent protein deacylase sirtuin-5, mitochondrial, NAD-dependent deacetylase sirtuin-5, NAD-dependent lysine demalonylase and desuccinylase sirtuin-5, mitochondrial, and SIR2L5. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Over 90 citations in the literature describe the use of sirtuin 5 antibodies in research. Western Blot is a widely used application for these antibodies. Flow Cytometry, Immunofluorescence, and Immunohistochemistry are also common applications.