Anti-PTPN6 antibodies are used in the immunodetection of the protein protein tyrosine phosphatase non-receptor type 6. In humans, the canonical protein has a reported length of 595 amino acid residues and a mass of 67.6 kDa. Its subcellular localization is in the nucleus and cytoplasm. Up to 4 different isoforms have been reported for this protein. It is notably expressed in the spleen, skin, lymph node, lung, and appendix. A member of the Protein-tyrosine phosphatase protein family, PTPN6 is known to be involved with cell differentiation and cytokine-mediated signaling pathways. Synonyms for this target antigen include HCPH, HPTP1C, PTP-1C, SH-PTP1, SHP-1, SHP-1L, SHP1, and HCP. PTPN6 gene orthologs have been reported in the mouse, rat, bovine, zebrafish, chimpanzee and chicken species. Over 140 citations in the literature describe the use of PTPN6 antibodies in research. Western Blot is a widely used application for these antibodies. ELISA, Immunofluorescence, and Immunohistochemistry are also common applications.