Anti-FREM2 antibodies are used in the immunodetection of the protein FRAS1 related extracellular matrix 2. In humans, the canonical protein has a reported length of 3169 amino acid residues and a mass of 351.2 kDa. Its subcellular localization is in the cell membrane. Up to 2 different isoforms have been reported for this protein. A member of the FRAS1 protein family, FREM2 is known to be involved with the morphogenesis of anatomical structure and cell adhesion. Post-translational modifications have been described, including glycosylation.
The FREM2 marker can be used to identify Hippocampal Gyrus Neurons, Hippocampal Gyrus CA4 Neurons, Gray Matter Chandelier Neurons, Gray Matter Interneurons, and Brain Splatter Neurons.* Synonyms for this target antigen include ECM3 homolog, FRAS1 related extracellular matrix protein 2, and FRAS1-related extracellular matrix protein 2. FREM2 gene orthologs have been reported in the mouse, rat, bovine, frog, chimpanzee and chicken species. Some FREM2 antibodies may have been used in research and have associated citations. ELISA is a widely used application for these antibodies. Western Blot, Immunocytochemistry, and Immunofluorescence are also common applications.
*HuBMAP Human Reference Atlas v1.4