Anti-SPHK2 antibodies are used in the immunodetection of the protein sphingosine kinase 2. In humans, the canonical protein has a reported length of 654 amino acid residues and a mass of 69.2 kDa. Its subcellular localization is in the nucleus, mitochondria, ER, and cytoplasm. Alternative splicing is reported to yield 5 different isoforms for this protein. It is reported to be mainly expressed in adult kidney, liver, and brain. SPHK2 is known to catalyze the phosphorylation of sphingosine to form sphingosine-1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Post-translational modifications have been described, including protein cleavage and phosphorylation.