Anti-Epsin 2 antibodies are used in the immunodetection of the protein encoded by the EPN2 gene. In humans, the canonical protein has a reported length of 641 amino acid residues and a mass of 68.5 kDa. Its subcellular localization is in the cytoplasmic vesicles and cytoplasm. Alternative splicing is reported to yield 4 different isoforms for this protein. A member of the Epsin protein family, it is reported to play a role in in the formation of clathrin-coated invaginations and endocytosis. Post-translational modifications have been described, including ubiquitination. Other names for this target antigen include EPS-15-interacting protein 2, Eps15 binding protein, and EHB21.