Anti-ACVRL1 antibodies are used in the immunodetection of the protein activin A receptor like type 1. In humans, the canonical protein has a reported length of 503 amino acid residues and a mass of 56.1 kDa. Its subcellular localization is in the cell membrane. It is notably expressed in many tissues, such as the caudate and cerebellum. A member of the TKL Ser/Thr protein kinase protein family, ACVRL1 is known to be involved with angiogenesis and cardiac tissue development. Post-translational modifications have been described, including glycosylation. The ACVRL1 gene has been associated with the disease, Telangiectasia. Synonyms for this target antigen include ALK-1, ALK1, HHT, HHT2, ORW2, SKR3, TSR-I, and ACVRLK1. ACVRL1 gene orthologs have been reported in the mouse, rat, bovine, frog, chimpanzee and chicken species.