Anti-Transferrin Receptor 2 antibodies are used for the immunodetection of the protein encoded by the TFR2 gene. In humans, the canonical protein has a reported length of 801 amino acid residues and a mass of 88.8 kDa. Its subcellular localization is in the cell membrane and cytoplasm. Alternative splicing is reported to yield 3 different isoforms for this protein. It is reported to be highly expressed in the liver. A member of the Peptidase M28 protein family, it is known to mediate cellular uptake of transferrin-bound iron in a non-iron dependent manner. Post-translational modifications have been described, including glycosylation. Other names for this target antigen include TFRC2, transferrin receptor protein 2, and HFE3. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish and chimpanzee species. A number of Transferrin Receptor 2 antibodies have been mentioned in research publications and have associated citations. Western Blot is a widely used application for these antibodies. In addition, Immunohistochemistry is also a common application.