What are Caspase 7 antibodies?
Anti-Caspase 7 antibodies are immunoglobulins that specifically recognize and bind caspase-7, a thiol protease encoded by CASP7 in humans. In research applications, these antibodies are used to detect caspase-7 in tissue samples, cell lysates, and cultured cells. Caspase-7 is involved in programmed cell death processes including apoptosis, pyroptosis, and granzyme-mediated cell death, proteolytically cleaving target proteins with a marked preference for the Asp-Glu-Val-Asp (DEVD) consensus sequence. Detecting caspase-7 and its cleaved, active fragment supports research into apoptotic signaling and resistance to cell death in cancer.
Catalog highlights and purchasing considerations
About the Biocompare Caspase 7 antibody catalog
The Biocompare antibody search tool lists anti-Caspase 7 antibodies from a range of suppliers, spanning unconjugated and fluorophore- or enzyme-conjugated formats. Listings may also appear under the gene symbol CASP7. Western blot is the most common validated application among these listings, followed by immunohistochemistry and ELISA. Several Caspase 7 antibodies mentioned here have been cited across a range of apoptosis research, including L-ICON3-mediated suppression of endometriosis, survivin-driven apoptotic resistance restored to irinotecan sensitivity in TP53-mutant colorectal cancer, and acetogenin-induced TNFR1-mediated cell death in head and neck cancer.
Considerations when choosing a Caspase 7 antibody for research
Confirm that the antibody's intended target is accurate, as many genes carry synonym symbols that can create ambiguity across suppliers. Specificity should be verified against the immunogen sequence or region listed on the product datasheet, since antibodies raised against different epitopes of the same protein can behave differently across applications. Beyond specificity, several target-related attributes can affect antibody binding, including subcellular location, extracellular and cytoplasmic domain boundaries for membrane-associated targets, tissue specificity, post-translational modifications, and the presence of additional isoforms or disease-associated variants. In parallel, antibody-specific selection criteria warrant consideration, including clonality (monoclonal versus polyclonal), host species, species reactivity, and conjugate or label choice suited to the detection method. Supplier validation data, such as western blot bands at the expected molecular weight, immunohistochemistry staining patterns consistent with known tissue distribution, and knockout or knockdown controls, should also be carefully reviewed before purchase.