Anti-RIGI antibodies are used in the immunodetection of the protein RNA sensor RIG-I. In humans, the canonical protein has a reported length of 925 amino acid residues and a mass of 106.6 kDa. Its subcellular localization is in the cytoplasm. Up to 2 different isoforms have been reported for this protein. It is notably widely expressed in many tissue types. A member of the Helicase protein family, RIGI is known to be involved with innate immune responses. Post-translational modifications have been described, including ubiquitination, sumoylation, protein cleavage and phosphorylation. Synonyms for this target antigen include RIG1, RLR-1, SGMRT2, antiviral innate immune response receptor RIG-I, ATP-dependent RNA helicase DDX58, and DDX58. Some RIGI antibodies may have been used in research and have associated citations. Western Blot is a widely used application for these antibodies. ELISA and Immunohistochemistry are also common applications.