Editorial Articles

Comprehensive overviews of enabling tools and techniques, as well as trends, researched and written by Biocompare writers.

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Multiple Options for Faster Western Blotting
March 01, 2012
Western blotting is a foundation technique for protein chemistry. The basic technique—transferring size-separated protein bands from a gel onto a ... read more
The Latest Tools and Approaches for Glycoprotein Analysis
May 10, 2012
Most eukaryotic proteins are controlled by a series of chemical switches, or post-translational modifications. Glycosylation, the coupling of proteins... read more
Super Clear Images with Super-resolution Microscopy
May 15, 2012
Although microscopists routinely generate beautiful, clear images, those images still suffer from one significant limitation: the diffraction limit. A... read more
Getting to the Right Answer with High-Resolution Mass Spectrometry
May 22, 2012
As its name implies, a high-res mass spectrometer is any instrument capable of resolving closely spaced spectral peaks, such that what appears to be, ... read more
SNP Genotyping Takes Advantage of Faster Sequencing
June 06, 2012
Genetics moves at a dizzying pace these days. Research journals trumpet new genetic associations almost daily for everything from disease ... read more
Accurate Mass Measurements with ESI-TOF Mass Spectrometers
June 12, 2012
ESI requires no matrix. Instead, samples typically are injected into the instrument via either a syringe pump or liquid chromatography interface, such... read more
cDNA Synthesis For Real-Time PCR
June 19, 2012
Real-time, or quantitative, PCR (qPCR) has quickly become instrumental for quantifying DNA and for quantifying RNA in gene expression studies by ... read more
Protein Tagging Technologies: New Ways to Tag and Track Your Protein
June 26, 2012
The simplest way to study a given protein—whether it’s a question of abundance, location, turnover, interaction partners or post-translational ... read more
Laser Capture Microdissection (LCM): The First Step in Single Cell Analysis
July 02, 2012
Eukaryotic tissue is, as we all know, not homogenous. It is built of different cell types, with distinct functions, morphologies and gene expression ... read more
Cell-Based Assays: Stepping Stones to Animal Studies
July 10, 2012
Cell-based assays, important systems in their own right for testing physiological processes, have become a powerful means to predict the outcome of in... read more
Quantification of Complex Samples Using Multiple Reaction Monitoring
July 17, 2012
Quantification on a triple quad is generally accomplished via a tandem MS/MS assay known as selected reaction monitoring (SRM; also called single ... read more
Nonradioactive Ligand-Binding Assays: Are Radiolabels PassÉ?
July 24, 2012
Ligand-binding assays have long been a staple for researchers who need to know when and how strongly two species bind. Examples include agonists ... read more
Cancer Diagnostics – New Ways of Looking at Cancer Progression and Treatment
July 31, 2012
When cell signaling pathways go awry, uncontrolled growth of cancer cells may result. But there are so many types of cancer, in all kinds of cells, ... read more
Choosing the Right Stem Cell Media
August 07, 2012
Key considerations in selecting the appropriate stem cell media include your intended application with the stem cells, the media components your cells... read more
Tools for Identifying DNA Methylation Targets
August 21, 2012
When it comes to eukaryotic heredity, the genome, as they say, is only the beginning. There’s also the epigenome, a set of heritable chemical ... read more
Tips for Optimizing Western Blot Protocols
August 21, 2012
Western blotting remains the most commonly used method for separating and detecting proteins, and yet it can be very difficult to make it work to your... read more