Great for Astrocyte Staining

Pediatric Neurology, CU Anschutz
Postdoctoral Researcher

Overall

Quality of Results

Ease-of-Optimization

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Company:

Cell Signaling Technologies

Product Name:

GFAP Monoclonal Antibody

Catalog Number:

cst3670

Clone Number:

GA5

Info:Supplier Page

Browse Similar Products: GFAP Monoclonal Antibody Products

We work on using stem cells to model and treat rare pediatric diseases. We differentiate patient-derived iPSCs into neural cells including astrocytes and utilize this antibody as an astrocyte immunofluorescence marker.

Experimental Design and Results Summary

Applications

Immunofluorescence

Sample

Human differentiated astrocytes

Primary Incubation

Diluted 1:200 in IF buffer (1X PBS+ 5% Normal Donkey Serum+0.3% Triton X-100) for 1hr at room temperature

Blocking Agent

IF buffer (1X PBS+ 5% Normal Donkey Serum+0.3% Triton X-100) for 1hr at room temperature

Secondary Incubation

Mo. Cy5 IgG (Jackson Immunoresearch) 1:500 in IF buffer (1X PBS+ 5% Normal Donkey Serum+0.3% Triton X-100) for 1hr at room temperature

Tertiary Incubation

Hoescht 1:10,000 in 1X PBS for 5mins at room temperature

Detection

Imaged on EVOS Fl Auto at 20x magnification

Results Summary

Patient-derived iPSCs from a rare neurological condition were differentiated into neural cell types. Immunofluorescence with this antibody has stained astrocytes in the mixed cell population allowing for further identification and analysis.

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Summary

The Good

Clear signal, well cited

The Bad

None

The Bottom Line

Great standard antibody for astrocyte staining

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