Cost Effective ER Marker Antibody

Health Division of Gastroenterology
UC Davis

Overall

Quality of Results

Ease-of-Optimization

What do these ratings mean?
Write a Review

Company:

Proteintech

Product Name:

calreticulin Polyclonal antibody

Catalog Number:

10292-1-AP

Clone Number:

We are interested in understanding the function of a endososome-localized enzyme and use this anti-Calreticulin antibody as ER marker to validate its subcellular localization not to be in ER. Using sucrose gradient centrifugation and western blotting, we are able to show the enzyme not present in the Calreticulin- fraction.

Experimental Design and Results Summary

Applications

Western Blot

Sample

HEK293T cells

Primary Incubation

1:1000 dilution overnight in the cold room

Blocking Agent

3% BSA in PBS

Secondary Incubation

1:10000 goat anti-rabbit

Tertiary Incubation

1hr incubation at room temp

Detection

LICOR fluorescence

Results Summary

We are interested in understanding the function of an endosome-localized enzyme and use this anti-Calreticulin antibody as an ER marker to validate its subcellular localization to be not in ER. Using sucrose gradient centrifugation and western blotting, we are able to detect that the enzyme is not to be in this Calrericulin-containing ER fraction.

Image Gallery

Summary

The Good

Specific and cost-effective

The Bad

Nothing

The Bottom Line

This is a cost-effective ER marker antibody

Share your experience with other scientists. Write a Review! »

Join the discussion