KO-validated TSC2 Detection for mTOR Signaling

Biochemistry
Stanford University
Postdoctoral Researcher

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Company:

Proteintech

Product Name:

Tuberin/TSC2 Polyclonal antibody

Catalog Number:

24601-1-AP

Clone Number:

I study signaling pathways, with a focus on the TSC1/TSC2–mTORC1 axis that controls growth and nutrient sensing. I use this antibody to monitor TSC2 (Tuberin) levels by western blot IN TSC2 KO cells when probing how perturbations affect mTOR pathway activity.

Experimental Design and Results Summary

Applications

Western Blot

Sample

Cell lysate

Primary Incubation

1:1000

Blocking Agent

5% milk in TBST

Secondary Incubation

None

Tertiary Incubation

None

Detection

Chemiluminescence

Results Summary

Detected endogenous TSC2 as a single specific band that disappeared in sh/KO controls, cleanly confirming knockdown/knockout and enabling reliable pathway analysis.

DOI or PMID #

N/A

Image Gallery

Summary

The Good

KO-validated with clean, specific signal

The Bad

none

The Bottom Line

knockout-validated TSC2 antibody that gives clean western blots for mTOR signaling studies

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