Did Not Detect pTAK1 After TNF Stimulation

R&D
EydisBio Inc.
Principal Investigator

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Quality of Results

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Company:

Cell Signaling Technologies

Product Name:

Phospho-TAK1 (Ser412) Antibody

Catalog Number:

9339S

Clone Number:

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We tested this Ab to determine if pTAK1 expression was increased following TNF stimulation. We observed by western blot that there was expression but we did not see up regulation. Its unclear if this was due to the sample or the Ab.

Experimental Design and Results Summary

Applications

Western Blot

Sample

Human PBMC's

Primary Incubation

1:500

Blocking Agent

Normal Donkey Serum

Secondary Incubation

1:1000

Tertiary Incubation

None

Detection

HRP Westernblot Reader

Results Summary

We detected pTAK1 Ser412 with this Ab. The band was at the right MW but we did not see any increased in TNF stimulated samples at 5, 15 and 30 minutes post stimulation.

DOI or PMID #

N/A

Additional Notes

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Summary

The Good

May detect pTAK1

The Bad

No up regulation post TNF treatment

The Bottom Line

This Ab may work but in our hands we did not see consistent results.

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