High-Purity DSPC for Stable mRNA Lipid Nanoparticle Formulations

July 01, 2026

BlueskyReddit
University of Florida
Neurosurgery
Research Scientist

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Questions/Comments

Company:

Avanti Research

Product Name:

18:0 PC (DSPC) – 1,2-Distearoyl-sn-glycero-3-phosphocholine

Catalog Number:

850365P-200mg

I used DSPC as the structural phospholipid in mRNA lipid nanoparticle (LNP) formulations at 30 mol% of the total lipid composition. It consistently produced stable nanoparticles and contributed to maintaining particle integrity during formulation and storage.

Experimental Design and Results Summary

Application

Structural phospholipid for mRNA lipid nanoparticle (LNP) formulation.

Starting Material

Tips

DSPC dissolves readily in ethanol and mixes uniformly with other lipid components. We used 30 mol% DSPC to provide structural stability to the lipid nanoparticles while maintaining reproducible particle formation during microfluidic mixing.

Results Summary

Using DSPC at 30 mol% consistently generated homogeneous and stable LNPs with good particle integrity. As the structural phospholipid, DSPC contributed to membrane stability and reproducible nanoparticle formation while supporting efficient mRNA encapsulation.

DOI or PMID #

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Summary

The Good

High purity and excellent batch-to-batch consistency

The Bad

N/A

The Bottom Line

Avanti DSPC is a reliable structural lipid for mRNA-LNP formulations. Using 30 mol% of the total lipid composition provided consistent nanoparticle formation, excellent membrane stability, and reproducible formulation performance, making it a dependable component for research and formulation development.

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