Engineering High-Performance LNPs with MedChemExpress Ionizable Lipids

June 24, 2026

BlueskyReddit
University of Florida
Neurosurgery
Research Scientist

Overall

Quality of Results

Ease-of-Optimization

What do these ratings mean?
Write a Review
Questions/Comments
  • Review Image
  • Review Image

Company:

MedChemExpress

Product Name:

SM-102

Catalog Number:

HY-134541

SM-102 was used as the ionizable lipid component in mRNA lipid nanoparticle (LNP) formulations prepared using a NanoAssemblr microfluidic mixer. The lipid showed excellent ethanol solubility, enabled robust nanoparticle formation when combined with helper lipids, cholesterol, and PEG-lipids, and consistently produced high-quality LNPs suitable for mRNA delivery studies.

Experimental Design and Results Summary

Application

Lipid Nanoparticle (LNP) Formulation

Starting Material

Lipid

Tips

SM-102 dissolves readily in ethanol and is easy to incorporate into lipid mixtures.

Results Summary

SM-102 was used as the ionizable lipid component in mRNA LNP formulations prepared by microfluidic mixing. The lipid demonstrated excellent ethanol solubility and reproducible formulation performance, generating nanoparticles with favorable size distribution, low PDI, and high mRNA encapsulation. Minimal optimization was required, and formulations were highly consistent across batches.

DOI or PMID #

N/A

Related Categories

Image Gallery

  • Review Image
  • Review Image

Summary

The Good

Excellent ethanol solubility, easy handling, reproducible LNP formation, and consistent nanoparticle quality.

The Bad

No significant drawbacks observed during formulation and characterization.

The Bottom Line

A high-quality ionizable lipid for mRNA LNP formulation that is easy to formulate and consistently produces robust nanoparticles with minimal optimization.

Join the discussion