Reliable Microglial Staining with Excellent Morphological Resolution

SUNY UB
Research Scientist

Overall

Quality of Results

Ease-of-Optimization

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Company:

Wako

Product Name:

Anti-Iba1 Antibody

Catalog Number:

019-19741

Clone Number:

N/A

We utilized this antibody to evaluate microglial activation in the mouse hippocampus after astrocyte-specific MOR knockdown. The staining quality was exceptional, allowing for clear visualization of both ramified and activated microglial morphology.

Experimental Design and Results Summary

Applications

Immunofluorescence

Sample

Mouse hippocampal sections

Primary Incubation

1:1000 overnight at 4°C

Blocking Agent

3% normal goat serum + 0.3% Triton X-100 in PBS

Secondary Incubation

Goat anti-rabbit Alexa Fluor 633, 1:1000, 1 h RT

Tertiary Incubation

NA

Detection

Confocal imaging

Results Summary

The antibody provided robust microglial labeling with excellent morphological resolution and minimal background staining, making it well suited for ramification index analysis and co-labeling with mCherry and DAPI.

DOI or PMID #

N/A

Additional Notes

N/A

Image Gallery

Summary

The Good

Excellent morphology detail and reproducible staining.

The Bad

Requires careful optimization of imaging settings for dense hippocampal regions.

The Bottom Line

A very dependable antibody for microglia visualization and activation studies.

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