Discover the Perfect ICAM-1 Antibody, for Achieving Remarkable Immunofluorescence Staining

Physiology
University of Tennessee HSC
Postdoctoral Researcher

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Company:

Thermo Fisher Scientific

Product Name:

ICAM-1 Monoclonal Antibody (1A29)

Catalog Number:

MA5407

Clone Number:

1A29

The ICAM-1 monoclonal antibody was obtained from ThermoFisher Scientific to stain ICAM-1 in human endothelial cells. Endothelial cells were grown until full confluence, then subjected to growth arrest and fixed in paraformaldehyde. Subsequently, the cells were immunofluorescence-stained with the ICAM-1 monoclonal antibody. Observations were made using a fluorescent microscope, and images were captured. As a negative control, cells stained with control IgG were included in the experiment. The selection of the antibody from ThermoFisher Scientific was based on the information provided in their antibody flyer.

Experimental Design and Results Summary

Applications

Immunofluorescence

Sample

Human endothelial cells

Primary Incubation

1:200 dilution, overnight at 4 degree celsius.

Blocking Agent

5% BSA

Secondary Incubation

Goat anti-mouse IgG Alexa Fluor 568, 2 hours at RT

Tertiary Incubation

None

Detection

Fluorescent microscopy

Results Summary

The ICAM-antibody from Thermo Fisher Scientific specifically detected ICAM-1 proteins in the cell junctions.

DOI or PMID #

N/A

Additional Notes

None.

Related Categories

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Summary

The Good

It is a highly specific antibody for human ICAM-1.

The Bad

None.

The Bottom Line

We found this antibody as an excellent choice for the immunofluorescence detection of ICAM-1 in human primary endothelial cells.

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