Superb Electrocompetent Cells for CRISPR Library Preparation

Stanford University
Biochemistry
Postdoctoral Researcher

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Company:

Invitrogen

Product Name:

ElectroMAX Stbl4 Competent Cells

Catalog Number:

11635018

I am using ElectroMAX Stbl4 Competent Cells to prepare a CRISPR library for a fitness screen. These cells are excellent for high transformation efficiency and for maintaining unstable DNA inserts, such as retroviral sequences, and direct repeats, which are present on the lentil plasmids.

Experimental Design and Results Summary

Application

Cloning

Starting Material

Plasmid containing library

Tips

Keep on ice before electroporation.

Results Summary

I observed that ElectroMAX Stbl4 Competent Cells demonstrated exceptionally high efficiency during electroporation, facilitating robust transformation rates ideal for CRISPR library preparation. The guide representation was ideal in these cells.

DOI or PMID #

N/A

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Summary

The Good

High efficiency.

The Bad

Costly.

The Bottom Line

These competent cells offer transformation rates essential for CRISPR library preparation and maintenance of unstable genetic elements.

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