Sigma-Aldrich
1,6-Hexanediol
240117
Info:Supplier Page
I used 1,6-hexanediol to dissolve nuclear condensates, disrupting liquid-liquid phase separation and enabling the study of transcriptional responses in my research on cellular stress adaptation.
Dissolving condensates
Cells expressing intrinsically disordered proteins prone to phase separation.
Use a range of concentrations based on the protein you are studying.
Using 5% hexanediol, I successfully dissolved condensates in 293T cells, providing valuable insights into the dynamic nature of these structures in my research.
N/A
Works great.
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Good chemical for studying importance of phase separation in biological response.