Good Antibody From R&D Systems to Detect 4EBP1 in Mouse Tissue.

Physiology
University of Tennessee HSC
Postdoctoral Researcher

Overall

Quality of Results

Ease-of-Optimization

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Company:

R&D Systems

Product Name:

Anti-4EBP1 Antibody

Catalog Number:

AF3227

Clone Number:

N/A

To measure 4EBP1 in a disease model, the mouse was given a specific treatment, euthanized, and tissue samples were collected. The protein extracts from these tissue samples were immunoprecipitated with 4EBP1 antibody and the immunocomplexes were resolved in 12% denaturing gels and immunoblotted for the target protein. The selection of antibodies was based on the specificity of the antibody shown in the flyer.

Experimental Design and Results Summary

Applications

Immunoprecipitation

Sample

Mouse tissue protein extract

Primary Incubation

Dilution (1:1000) in 5% BSA prepared in 1x TBST, overnight incubation at 4 degrees celsius.

Blocking Agent

5% skimmed milk prepared in 1x TBST.

Secondary Incubation

Bovine anti-goat-IgG HRP Antibody, dilution (1:4000) in 5% skimmed milk prepared in 1x TBST, 2hr at RT.

Tertiary Incubation

None

Detection

Enhanced chemiluminescent detection in X-Ray films.

Results Summary

The antibody has detected a very strong and intense band of the 4EBP1-test protein complex, and this shows the specificity of this antibody was high for its on-target epitope.

DOI or PMID #

None

Additional Notes

None

Image Gallery

Summary

The Good

This antibody is good for 4EBP1 immunoprecipitation.

The Bad

None.

The Bottom Line

A specific antibody.

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