MedChemExpress
Verteporfin
HY-B0146
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I used verteporfin to treat my colorectal cancer patient-derived organoids. Realtime PCR analyses for expression of its direct target YAP1 as well as YAP1 downstream targets were performed. The MedChemExpress Verteporfin provided a very good inhibition at 5uM in vitro.
In vitro cell culture
Colorectal cancer organoids
Solubility >50mg/mL in 100% DMSO
I dissolved this inhibitor using 100% DMSO and then treated patients derived cancer organoids with either 0.1% DMSO or 5uM Verteporfin and confirmed its inhibitory effect by checking transcription of YAP1 and its targets. The product showed satisfactory inhibition of YAP1.
N/A
Cost is relatively lower but quality is as good.
This molecule significantly inhibited YAP1 signaling and transcription of both YAP1 and its targets CYR61 and CTGF.