Great Antibody for Nuclear Pore Localization in ICC

Genetics
Middle East Technical University
Graduate Student

Overall

Quality of Results

Ease-of-Optimization

What do these ratings mean?
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Company:

BioLegend

Product Name:

Purified anti-Nuclear Pore Complex Proteins Antibody

Catalog Number:

902907

Clone Number:

MAb414

I used Leica SP8 confocal microscope to visualize HEK293 nuclear pore complex proteins and this antibody worked great. Cells were fixed with 4% PFA and permeabilized with %0.1 Triton X-100. Incubation done at 4°C for overnight. I used Alexa Fluor® 594 Goat anti-mouse IgG (minimal x-reactivity) Antibody as a secondary antibody.

Experimental Design and Results Summary

Applications

Immunofluorescence

Sample

HEK293

Primary Incubation

Overnight at 4°C. 1:200 dilution.

Blocking Agent

BSA

Secondary Incubation

3 hours at R/T with secondary Ab

Tertiary Incubation

N/A

Detection

Leica SP8 Confocal Microscope

Results Summary

I could even see the nuclear pores in very low resolutions. The unspecific binding looks very minimal and the image was quite clean.

DOI or PMID #

N/A

Additional Notes

N/A

Image Gallery

Summary

The Good

Good binding. Minimal unspecific binding.

The Bad

No bad side.

The Bottom Line

Great antibody, looks like a must!

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