Excellent Sonicator for Chromatin Sharing

University of Cote d'Azur (UCA)
LP2M
Research Scientist

Overall

Performance

Ease-of-Optimization

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Company:

Covaris

Product Name:

S220 Focused-ultrasonicator

Catalog Number:

500217

Our studies focused on the epigenetic modification in different tissues (kidney, adrenal gland, renal precursors). Proper chromatin fragmentation is essential for the downstream analysis. This equipment drastically increased the quality of this step thanks to the focused sonication and the temperature control.

Experimental Design and Results Summary

Application

Chromatin fragmentation

Tips

Optimisation of the parameters is required for each cell type or tissue used.

DOI or PMID #

N/A

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Summary

The Good

Sample is maintained cold, total control on the parameters, focused sonication requires less power

The Bad

Requires dedicated consumables (glass vessels).

The Bottom Line

Excellent sonicator that allows full control on the parameters, while maintaining the sample at controlled temperature. Despite the cost of the machine and the dedicated consumables, I highly recommend this equipment to all the studies focused on epigenetic.

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