Very Bright 2nd Antibody

Neuroscience
UAB
Postdoctoral Researcher

Overall

Quality of Results

Ease-of-Optimization

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Company:

Thermo

Product Name:

Donkey anti-Rabbit IgG (H+L) Highly Cross-Adsorbed Secondary Antibody, Alexa Fluor 488

Catalog Number:

A-21206

Clone Number:

This is the best 2nd antibody I have used in years of experience and performing IF experiments. This is a very specific antibody that works very well in a wide range of concentrations.

Experimental Design and Results Summary

Applications

Immunofluorescence

Sample

Mouse brain

Primary Incubation

Incubation was done with Ab diluted to 1:1,000 for 16h at 4ºC

Blocking Agent

BSA 4% in PBS

Secondary Incubation

Incubation was done with 2nd Ab diluted to 1:1,000 for 1h at room temperature

Tertiary Incubation

none

Detection

Fluorescence (AF 488)

Results Summary

The reactivity of this 2nd antibody is quite good at 1:1,000 dilution. This fluorescence is available in many fluorescence microscope configurations. I have captured this image in my confocal to show fluorescence of Alexa 488 in the mouse hypothalamus, after incubation with a primary antibody.

DOI or PMID #

Additional Notes

Image Gallery

Summary

The Good

Reliable and sensible

The Bad

None

The Bottom Line

Great secondary antibody!

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