Cells Fixation Buffer Before Flow Cytometry Analysis

University of Tennessee HSC
College of Medicine
Postdoctoral Researcher

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Company:

BD Biosciences

Product Name:

BD Cytofix™ Fixation Buffer

Catalog Number:

554655

When I cannot acquire the stained samples on the same day, it requires fixing the cells. To fix the cells, I used this BD Cytofix buffer added to the samples for 30 minutes and incubated at 4 degrees celsius. After that, I washed the samples twice with stain buffer to preserve the cell markers in their original state for the next day's run.

Experimental Design and Results Summary

Application

Flow Cytometry

Starting Material

Human PBMCs

Tips

Before adding the fixation buffer vortex the cells.

Results Summary

After acquiring the fixed cells on the 2nd-day on the flow cytometer, all signals were observed good.

DOI or PMID #

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Summary

The Good

This buffer can also be used for cell fixation require for intracellular staining.

The Bad

It contains toxic substance.

The Bottom Line

Regularly used and ready to use buffer for the flow related samples.

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